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Nov 28, 2019

My guest on today's podcast - Dr. David Sinclair, an acclaimed Harvard Medical School scientist and named as one of Time’s most influential people - just wrote a paradigm-shifting book.

It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan?

In this groundbreaking new book Lifespan: Why We Age―and Why We Don't Have To, Dr. Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”

This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging.

The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger.

Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer.

At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

During our discussion in which we take a deep dive into "Lifespan", you'll discover:

-What does a typical day look like for a scientist at Harvard?...5:45

-Dr. Sinclair's method of speeding up the aging process in mice...8:30

-Cellular Reprogramming 101...14:30-A device that determines a human genome via a USB connection...23:15

-Whether you can predict your lifespan with your current DNA data from 23andMe...25:15

-The correlation between protein consumption and longevity...29:30

-The importance of a proper methionine and glycine balance...38:00

-The effects of NMN on fertility...49:15

-Uncoupling proteins, and whether DMP supplements are a good idea...53:10

-Resveratrol, stressed wine and fruit, and longevity...58:00

-Cancer breakthroughs in which Dr. Sinclair is currently interested...1:03:15

-David's personal protocol...1:10:30

-And much more...

Resources from this episode:

-Dr. Sinclair's website and newsletter

- Book:  Lifespan: Why We Age―and Why We Don't Have To

- Chris Masterjohn Methionine Glycine balance database

- Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43 (Roh, 2018)

- Dr. William Davis yogurt recipe

- Aging journal

- Article on Nature about Steven Horvath's study on the "epigenetic clock"

- Jump Start Fertility

- Continuum Biosciences

- Dry Farm Wines

- BGF podcast w/ Todd White of Dry Farm Wines

Episode sponsors:

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Do you have questions, thoughts or feedback for David or me? Leave your comments below and one of us will reply!