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Jun 20, 2019

This audio/video overview by Dr. Ally Perlina of Viome goes in depth on Ben's latest gut microbiome results from Viome. In this episode, you'll learn how to customize your diet and lifestyle based on the genetics of your gut.

Dr. Perlina is the Chief Translational Science Officer at Viome. She leads the Viome team on the development of actionable pathway analytics, functional microbiome profiling, and integration of Viome test results into food and supplement recommendation logic. Ally came to Viome from working with Dr. Craig Venter at Human Longevity, Inc.

She brings over 17 years of industry experience, which include Thomson Reuters, Quest Diagnostics, and several startup organizations where she led R&D groups, scientific product development efforts, and translated knowledge and insights from clinical data analyses into actionable results. S

he’s a world-class expert in pathway analysis and translational systems biology, which are critical in addressing the complexities of health and disease from different data types in a meaningful holistic way.

This cross-functional perspective and passion for making scientifically powered precision medicine insights actionable and scalable has been Ally’s driving force ever since she was investigating gene expression correlates of brain tumors and patient drug response at UCLA while getting her doctorate training in Human Genetics.

Ally’s ability to “translate” the signals from genomics, transcriptomics, metabolomics, etc., into something valuable for human health today allows her to lead a diverse team of scientific, clinical, and nutritional experts that together with data science make truly personalized Viome recommendations with molecular-level precision

To learn more about Viome and what it is, you can click here or check out these previous resources I've created on this cutting-edge way to test all the bacteria in your gut, along with the postbiotics they produce:

- Article: What Is Viome? How Gut Metatranscriptome & Microbiome Analysis Can Change Your Health 

- Podcast: Age Reversing Via The Gut, The Ultimate Anti-Anxiety Pill, Customized Probiotics & More With Billionaire Entrepreneur & Viome Founder Naveen Jain

- Podcast: Poop, Bacteria & You: The Latest Cutting-Edge Science Of The Human Microbiome (& How To Affordably Test Your Own Gut)

- Podcast: The Ultimate Guide To Self-Quantification – How To Test, Track & Interpret Blood, Saliva, Urine, Hair & Poop

During this audio/video, you'll discover:

-Ben's GI summary...7:23

  • Most important themes to address are several specific functions dealing with digestive efficiency
  • Active microbes: There are 134 active microbial species detected in the sample, which means that Richness is within the average range but may need improvement.
  • No active Eukaryotes were detected
  • There are 2 active plant viruses:
    • Prunus necrotic ringspot
    • Pepper mild mottle

-Overall microbial richness...9:50

  • Ben's score is 134 out of 400; average score (5-95 percentile)
  • The microbial could use a boost, but nothing too alarming
  • Recommended foods:
    • Sauerkraut enriches and diversifies the microbiome
    • Walnuts increase microbial diversity
    • Olive oil contains MUFAs, which are a group of fatty acids; weight management, increases bacterial diversity, decreases inflammation
  • Recommended supplements:

-Metabolic fitness score...18:35

  • Ben's score is GOOD, in the 18th percentile of the Viome population (improved from Sep. 2018)

-Inflammatory activity...21:10

  • Ben's overall score is AVERAGE
  • LPS biosynthesis pathways: average
  • Methane gas production pathways: needs improvement
  • Sulfide gas production pathways: needs improvement
  • Flagella assembly pathways: average
  • Biofilm, chemotaxis, virulence pathways: average
  • Balance is the goal, not optimal scores in every area
  • Although the score is "average" it's on the higher end of the spectrum

-Proinflammatory microbial activity, and active pro inflammatory pathways that indicate potential GI inflammation...32:40

-Butyrate production pathways and active butyrate producers...45:45

  • Ben's overall score is GOOD
  • Butyrate is good for metabolic fitness
  • Regulates satiety, good for insulin sensitivity
  • Goes hand in hand with inflammation scores
  • Butyrate is a short chain fatty acid (SCFA); associated with beneficial functions for the host
  • Resistant starches and fibers: resist the digestive system of the host

-SCFA production pathways and active SCFA producing microbes...51:40

  • In addition to butyrate: acetate, acetyl phosphate
  • Active probiotic in Ben's sample
  • Many different pathways that lead to butyrate production

-Recommendations for Ben's diet...55:23

-Digestive efficiency...59:20

  • Ben's overall score is AVERAGE
    • Protein fermentation: needs improvement
    • Gas production: needs improvement
    • Methane gas production pathways: needs improvement
    • Sulfide gas production pathways: needs improvement
    • Putrescine production pathways: needs improvement
    • Butyrate production pathways: good
    • Salt stress pathways: good
  • Protein fermenters and active protein fermentation pathways
    • Omithine
    • Putrescine
    • Cadaverine
    • Ammonia
    • Urea
  • Recommendations related to protein fermentation:

-Hydrogen sulfide production pathways and hydrogen sulfide producing microbes...1:15:50

  • Exacerbated by certain foods
  • Disruptive to the gut lining
  • Proinflammatory if produced in excess
  • Sulfate (or sulfite) is deleterious
  • Recommendations specific to microbial gas production, particularly hydrogen sulfide:
    • Broccoli
    • Brussels sprouts

-Vitamins produced by the gut microbes and detox of the microbiome...

-And much more...

Resources mentioned:


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Do you have questions, thoughts or feedback for Dr. Ally or me? Leave your comments below and one of us will reply!